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NADH

Uses

Nicotinamide adenine dinucleotide (NADH) is the active coenzyme form of vitamin B3. It plays an essential role in the energy production of every human cell.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
Chronic Fatigue Syndrome
10 mg daily
Supplementing with NADH may help your body produce more energy.

(nicotinamide adenine dinucleotide) helps make ATP, the energy source the body runs on. In a double-blind trial, people with CFS received 10 mg of NADH or a placebo each day for four weeks. Of those receiving NADH, 31% reported improvements in fatigue, decreases in other symptoms, and improved overall quality of life, compared with only 8% of those in the placebo group. Further double-blind research is needed to confirm these findings.

2 Stars
Parkinson’s Disease
5 mg twice per day
NADH—the active form of vitamin B3 in the body—has been shown to reduce symptoms and improve brain function in people with Parkinson’s disease.

Drug therapy for Parkinson’s disease has been reported to deplete vitamin B3 in humans. Vitamin B3 may be needed to decrease SAMe levels, and in so doing, may possibly help people with Parkinson’s disease. However, the two main forms of vitamin B3, niacin and niacinamide, when taken in combination with L-dopa, have demonstrated no benefit for people with Parkinson’s disease. Nicotinamide adenine dinucleotide ()—the active form of vitamin B3 in the body—effectively raises the level of dopamine in the brain, making it potentially useful in the treatment of people with Parkinson’s disease. In preliminary research, NADH supplementation reduced symptoms and improved brain function in people with Parkinson’s disease. One researcher has recommended 5 mg taken twice per day for people with Parkinson’s disease. However, one small, double-blind, short-term trial using injections of NADH found no significant effects.

1 Star
Alzheimer’s Disease
10 mg per day
A small, preliminary trial showed that oral NADH improved mental function in people with Alzheimer’s disease.

A small, preliminary trial showed that oral (10 mg per day) improved mental function in people with Alzheimer’s disease. Further studies are necessary to confirm these early results.

1 Star
Depression
Refer to label instructions
One study suggested that supplementing with NADH may help people with depression.

An isolated preliminary trial suggests the supplement may help people with depression. Controlled trials are needed, however, before any conclusions can be drawn.

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