Ornithine

Uses

Ornithine, an amino acid, is manufactured by the body when another amino acid, arginine, is metabolized during the production of urea (a constituent of urine).

How It Works

How to Use It

Most people would not benefit from ornithine supplementation. In human research involving ornithine, 5–10 grams are typically used per day, sometimes combined with arginine.

Where to Find It

As with amino acids in general, ornithine is predominantly found in meat, fish, dairy, and eggs. Western diets typically provide 5 grams per day. The body also produces ornithine.

Possible Deficiencies

Since ornithine is produced by the body, a deficiency of this nonessential amino acid is unlikely, though depletion can occur during growth or pregnancy, and after severe trauma or malnutrition.1

Interactions

Interactions with Supplements, Foods, & Other Compounds

The presence of arginine is needed to produce ornithine in the body, so higher levels of this amino acid should increase ornithine production.

Interactions with Medicines

As of the last update, we found no reported interactions between this supplement and medicines. It is possible that unknown interactions exist. If you take medication, always discuss the potential risks and benefits of adding a new supplement with your doctor or pharmacist.
The Drug-Nutrient Interactions table may not include every possible interaction. Taking medicines with meals, on an empty stomach, or with alcohol may influence their effects. For details, refer to the manufacturers’ package information as these are not covered in this table. If you take medications, always discuss the potential risks and benefits of adding a supplement with your doctor or pharmacist.

Side Effects

Side Effects

Gastrointestinal distress has been reported with intakes over 10 grams of ornithine per day.

References

1. Zieve L. Conditional deficiencies of ornithine or arginine. J Am Coll Nutr 1986;5:167-76. [review]

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