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Vitamin B1

Uses

Vitamin B1 is is a water-soluble vitamin needed to process carbohydrates, fat, and protein. Every cell of the body requires vitamin B1 to form the fuel the body runs on—adenosine triphosphate (ATP). Nerve cells require vitamin B1 in order to function normally.

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
2 Stars
Alzheimer’s Disease
3 grams daily
Supplementing with vitamin B1 might slow Alzheimer’s disease progression in people whose vitamin B1–dependent enzymes have low activity.

is involved in nerve transmission in parts of the brain (called cholinergic neurons) that deteriorate in Alzheimer’s disease. The activity of vitamin B1-dependent enzymes has been found to be lower in the brains of people with Alzheimer’s disease. It has therefore been suggested that vitamin B1 supplementation could slow the progression of Alzheimer’s disease. Two double-blind trials have reported small but significant improvements of mental function in people with Alzheimer’s disease who took 3 grams a day of vitamin B1, compared to those who took placebo. However, another double-blind trial using the same amount for a year found no effect on mental function.

2 Stars
Anemia and Genetic Thiamine-Responsive Anemia
10 to 20 mg daily
Rare genetic disorders can cause anemias that may improve with large amounts of supplements such as vitamin B1.

Deficiencies of iron, vitamin B12, and folic acid are the most common nutritional causes of anemia. Although rare, severe deficiencies of several other vitamins and minerals, including vitamin A,vitamin B2,vitamin B6,vitamin C, and copper, can also cause anemia by various mechanisms. Rare genetic disorders can cause anemias that may improve with large amounts of supplements such as .

2 Stars
Hepatitis
100 mg daily
In a preliminary report, three patients with chronic hepatitis B had an improvement in the severity of their hepatitis after supplementing with thiamine (vitamin B1).

In a preliminary report, three patients with chronic hepatitis B had an improvement in the severity of their hepatitis after taking 100 mg of (vitamin B1) per day.

2 Stars
Low Back Pain (Vitamin B12, Vitamin B6)
Take under medical supervision: 50 to 100 mg each of vitamins B1 and B6, and 250 to 500 mcg of vitamin B12, all taken three times per day
A combination of vitamin B1, vitamin B6, and vitamin B12 may prevent a common type of back pain linked to vertebral syndromes and may reduce the need for anti-inflammatory medications.

A combination of , vitamin B6, and vitamin B12 has proved useful for preventing a relapse of a common type of back pain linked to vertebral syndromes, as well as reducing the amount of anti-inflammatory medications needed to control back pain, according to double-blind trials. Typical amounts used have been 50–100 mg each of vitamins B1 and B6, and 250–500 mcg of vitamin B12, all taken three times per day. Such high amounts of vitamin B6 require supervision by a doctor.

2 Stars
Type 1 Diabetes
25 mg vitamin B1 with 50 mg of vitamin B6 daily or 600 mg lipid-soluble thiamine (benfotiamine) daily
People with type 1 diabetes may be deficient in vitamin B1. Supplementing with vitamin B1 may restore levels and improve symptoms of diabetic neuropathy.

Blood levels of vitamin B1 (thiamine) have been found to be low in people with type 1 diabetes, and low levels are correlated with greater risk of diabetes-related anemia and other complications. Supplementing with B1, along with vitamins B6 and B12, was found to reduce high levels of homocysteine in children type 1 diabetes in one placebo-controlled trial. High homocysteine levels are generally correlated with blood vessel dysfunction and reducing high levels may help prevent vascular complications of diabetes. In this trial, improvement in markers of kidney function were also seen.

Several controlled trials have evaluated the effect of benfotiamine, a fat-soluble form of vitamin B1, on diabetic neuropathy in participants with type 1 and type 2 diabetes. In one of these trials, 600 mg per day of benfotiamine was more effective than 300 mg per day or placebo for reducing neuropathic pain after six weeks; in a three-week trial, those receiving 400 mg per day of benfotiamine had greater pain reduction than those receiving placebo. However, 300 mg of benfotiamine daily had no benefits on nerve function relative to placebo in people with type 1 diabetes after 24 months, suggesting this dose may be too low to be helpful.

2 Stars
Type 2 Diabetes and Diabetic Neuropathy (Vitamin B12)
Refer to label instructions
Taking vitamin B1 combined with vitamin B12 may improve symptoms of diabetic neuropathy.
A controlled trial in Africa found that supplementing with both vitamin B1 (25 mg per day) and vitamin B6 (50 mg per day) led to significant improvement of symptoms of diabetic neuropathy after four weeks. However, since this was a trial conducted among people in a vitamin B1–deficient developing country, these improvements might not occur in other people with diabetes. Another trial found that combining vitamin B1 (in a special fat-soluble form) and vitamin B6 plus vitamin B12 in high but variable amounts led to improvement in some aspects of diabetic neuropathy in 12 weeks. As a result, some doctors recommend that people with diabetic neuropathy supplement with vitamin B1, though the optimal level of intake remains unknown.
2 Stars
Type 2 Diabetes and Diabetic Neuropathy (Vitamin B6)
25 mg of vitamin B1 daily, with 50 mg of vitamin B6 daily
Taking vitamin B1 combined with vitamin B6 may improve symptoms of diabetic neuropathy.

A controlled trial in Africa found that supplementing with both vitamin B1 (25 mg per day) and vitamin B6 (50 mg per day) led to significant improvement of symptoms of diabetic neuropathy after four weeks. However, since this was a trial conducted among people in a vitamin B1–deficient developing country, these improvements might not occur in other people with diabetes. Another trial found that combining vitamin B1 (in a special fat-soluble form) and vitamin B6 plus vitamin B12 in high but variable amounts led to improvement in some aspects of diabetic neuropathy in 12 weeks. As a result, some doctors recommend that people with diabetic neuropathy supplement with vitamin B1, though the optimal level of intake remains unknown.

1 Star
Alcohol Withdrawal
Refer to label instructions
Supplementing with vitamin B1 (thiamine) may prevent brain damage and nerve disorders in people with alcoholism, including those withdrawing from alcohol.
Thiamine deficiency is very common among alcoholics, including those who are withdrawing from alcohol. Even short-term thiamine deficiency can cause irreversible damage to the brain and nervous system.
1 Star
Cardiomyopathy and Wet Beri Beri
Refer to label instructions
People with cardiomyopathy caused by severe vitamin B1 deficiency (known as wet beri beri) generally require intravenous vitamin B1, followed by oral supplementation.

The small proportion of people with cardiomyopathy whose disease is due to severe (thiamine) deficiency (known as wet beri beri) generally require intravenous vitamin B1, followed by oral supplementation. Vitamin B1 does not appear to be helpful for other types of cardiomyopathy. People requiring vitamin B1 for cardiomyopathy must first be diagnosed as having wet beri beri, and treatment must be supervised by a healthcare professional.

1 Star
Dysmenorrhea
Refer to label instructions
Vitamin B1 appears to relieve dysmenorrheal in cases of vitamin B1 deficiency. It is not known whether supplementing would relieve the condition in women who are not deficient.

In a double-blind trial, adolescents living in India who were suffering from dysmenorrhea took 100 mg of (thiamine) per day for three months. Eighty-seven percent of those treated experienced marked relief of dysmenorrhea symptoms. However, vitamin B1 deficiency is relatively common in India, whereas it is rare in the Western world, except among alcoholics. It is not known whether vitamin B1 supplementation would relieve dysmenorrhea in women who are not B1 deficient.

1 Star
Fibromyalgia
Refer to label instructions
People with fibromyalgia may be deficient in vitamin B1. Supplementing with the vitamin may correct the deficiency and improve symptoms.

Some studies have found low (thiamine) levels and reduced activity of some thiamine-dependent enzymes among people with fibromyalgia. The clinical significance of these findings remains unknown.

1 Star
HIV and AIDS Support
Refer to label instructions
People with AIDS often have thiamine (vitamin B1) deficiency, which may contribute to some neurological abnormalities, supplementing with the vitamin may help.

In HIV-positive people with B-vitamin deficiency, the use of B-complex vitamin supplements appears to delay progression to and death from AIDS. Thiamine () deficiency has been identified in nearly one-quarter of people with AIDS. It has been suggested that a thiamine deficiency may contribute to some of the neurological abnormalities that are associated with AIDS. Vitamin B6 deficiency was found in more than one-third of HIV-positive men; vitamin B6 deficiency was associated with decreased immune function in this group. In a population study of HIV-positive people, intake of vitamin B6 at more than twice the recommended dietary allowance (RDA is 2 mg per day for men and 1.6 mg per day for women) was associated with improved survival. Low blood levels of folic acid and vitamin B12 are also common in HIV-positive people.

1 Star
Multiple Sclerosis
Refer to label instructions
Thiamine (vitamin B1) deficiency may contribute to nerve damage. Researchers have found that injections of thiamine or thiamine combined with niacin may reduce symptoms.

Deficiency of (vitamin B1) may contribute to nerve damage. Many years ago, researchers found that injecting thiamine into the spinal cord or using intravenous thiamine combined with niacin in people with MS led to a reduction in symptoms. Using injectable vitamins requires medical supervision. No research has yet studied the effects of oral supplementation with B vitamins in people with MS.

1 Star
Pre- and Post-Surgery Health
Refer to label instructions
Vitamin B1, given as intramuscular injections before surgery, resulted in less reduction of immune system activity after surgery in one study.

, given as intramuscular injections of 120 mg daily for several days before surgery, resulted in less reduction of immune system activity after surgery in a preliminary trial. In a controlled trial, an oral B vitamin combination providing 100 mg of B1, 200 mg of vitamin B6, and 200 mcg of vitamin B12 daily given for five weeks before surgery and for two weeks following surgery also prevented post-surgical reductions in immune activity. However, no research has explored any other benefits of B vitamin supplementation in surgery patients.

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