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Iron

Uses

Iron is an essential mineral. It is part of hemoglobin, the oxygen-carrying component of the blood. Iron-deficient people tire easily in part because their bodies are starved for oxygen. Iron is also part of myoglobin, which helps muscle cells store oxygen. Without enough iron, adenosine triphosphate (ATP; the fuel the body runs on) cannot be properly synthesized. As a result, some iron-deficient people become fatigued even when their hemoglobin levels are normal (i.e., when they are not anemic).

What Are Star Ratings?

This supplement has been used in connection with the following health conditions:

Used for Why
3 Stars
Anemia and Iron Deficiency
If deficient: 100 mg daily for up to one year under medical supervision
Taking iron may help prevent and treat anemia; ask your doctor if it’s right for you. Deficiencies of iron, vitamin B12, and folic acid are the most common nutritional causes of anemia.

Deficiencies of , vitamin B12, and folic acid are the most common nutritional causes of anemia. Although rare, severe deficiencies of several other vitamins and minerals, including vitamin A,vitamin B2,vitamin B6,vitamin C, and copper, can also cause anemia by various mechanisms. Rare genetic disorders can cause anemias that may improve with large amounts of supplements such as vitamin B1.

3 Stars
Depression and Iron Deficiency
See a doctor for evaluation
A lack of iron can make depression worse; check with a doctor to find out if you are iron deficient.

Iron deficiency is known to affect mood and can exacerbate depression, but it can only be diagnosed and treated by a doctor. While iron deficiency is easy to fix with supplements, people who have not been diagnosed with iron deficiency should not supplement iron.

3 Stars
Iron-Deficiency Anemia
Consult a qualified healthcare practitioner
Supplementing with iron is essential to treating iron deficiency.

Caution: People should not supplement with iron unless diagnosed with iron deficiency, because taking iron when it isn’t needed has no benefit and may be harmful.

Before iron deficiency can be treated, it must be diagnosed and the cause must be found by a doctor. In addition to addressing the cause (e.g., avoiding aspirin, treating a bleeding ulcer, etc.), supplementation with iron is the primary way to resolve iron-deficiency anemia.

If a doctor diagnoses iron deficiency, supplementation is essential. Though some doctors use higher amounts, a common daily dose for adults is 100 mg per day. Even though symptoms of deficiency should disappear much sooner, iron deficient people usually need to keep supplementing with iron for six months to one year until the ferritin test is completely normal. Even after taking enough iron to overcome the deficiency, some people with recurrent iron deficiency—particularly some premenopausal women—need to continue to supplement with smaller levels of iron, such as the 18 mg present in most multivitamin-mineral supplements. This need for continual iron supplementation even after deficiency has been overcome should be determined by a doctor.

3 Stars
Menorrhagia and Iron Deficiency
100 to 200 mg daily under medical supervision if deficient
Supplementing with iron decreases excess menstrual blood loss in iron-deficient women who have no other underlying cause for their condition.

Since blood is rich in , excessive blood loss can lead to iron depletion. Iron deficiency can be identified with simple blood tests. If an iron deficiency is diagnosed, many doctors recommend 100–200 mg of iron per day, although recommendations vary widely.

The relationship between iron deficiency and menorrhagia is complicated. Not only can the condition lead to iron deficiency, but iron deficiency can lead to or aggravate menorrhagia by reducing the capacity of the uterus to stop the bleeding. Supplementing with iron decreases excess menstrual blood loss in iron-deficient women who have no other underlying cause for their condition. However, iron supplements should be taken only by people who have, or are at risk of developing, iron deficiency.

2 Stars
Athletic Performance and Iron Deficiency
Consult a qualified healthcare practitioner
Iron is a component of hemoglobin, which transports oxygen to muscle cells. In cases of iron deficiency, taking iron may restore levels and improve athletic performance.

is important for an athlete because it is a component of hemoglobin, which transports oxygen to muscle cells. Some athletes, especially women, do not get enough iron in their diet. In addition, for reasons that are unclear, endurance athletes, such as marathon runners, frequently have low body-iron levels. However, anemia in athletes is often not due to iron deficiency and may be a normal adaptation to the stress of exercise. Supplementing with iron is usually unwise unless a deficiency has been diagnosed. People who experience undue fatigue (an early warning sign of iron deficiency) should have their iron status evaluated by a doctor. Athletes who are found to be iron deficient by a physician are typically given 100 mg per day until blood tests indicate they are no longer deficient. Supplementing iron-deficient athletes with 100 to 200 mg per day of iron increased aerobic exercise performance in some, though not all, double-blind studies. A recent double-blind trial found that iron-deficient women who took 20 mg per day of iron for six weeks were able to perform knee strength exercises for a longer time without muscle fatigue compared with those taking a placebo.

2 Stars
Attention Deficit–Hyperactivity Disorder and Iron Deficiency
Consult a qualified healthcare practitioner
In one study, iron levels were significantly lower in a group of children with ADHD than in healthy children. In the case of iron deficiency, supplementing with the mineral may improve behavior.

status, as measured by the serum ferritin concentration, was significantly lower in a group of children with ADHD than in healthy children. Ferritin levels were below normal in 84% of the children with ADHD, compared with 18% of the healthy children. Since iron deficiency can adversely affect mood and cognitive function, iron status should be assessed in children with ADHD, and those who are deficient should receive an iron supplement. In a case report, a young boy with both ADHD and iron deficiency showed considerable improvement in behavior after receiving an iron supplement. Iron supplementation was also beneficial in a double-blind study of children with ADHD and iron deficiency.

2 Stars
Breast-Feeding Support and Iron Deficiency
Consult a qualified healthcare practitioner
Iron may be required for infants with low iron stores or anemia.
If a doctor diagnoses iron deficiency, iron supplementation is essential. Though some doctors use higher amounts, a common daily dose for adults is 100 mg per day. Even though symptoms of deficiency should disappear much sooner, iron deficient people usually need to keep supplementing with iron for six months to one year until the ferritin test is completely normal. Even after taking enough iron to overcome the deficiency, some people with recurrent iron deficiency—particularly some premenopausal women—need to continue to supplement with smaller levels of iron, such as the 18 mg present in most multivitamin-mineral supplements. This need for continual iron supplementation even after deficiency has been overcome should be determined by a doctor.
2 Stars
Canker Sores and Iron Deficiency
Consult with your doctor
Talk to your doctor to see if your recurrent canker sores might be related to iron deficiency.

Several preliminary studies, though not all, have found a surprisingly high incidence of and B vitamin deficiency among people with recurrent canker sores. Treating these deficiencies has been reported in preliminary and controlled studies to reduce or eliminate canker sore recurrences in most cases. Supplementing daily with B vitamins—300 mg vitamin B1, 20 mg vitamin B2, and 150 mg vitamin B6—has been reported to provide some people with relief. Thiamine (B1) deficiency specifically has been linked to an increased risk of canker sores. The right supplemental level of iron requires diagnosis of an iron deficiency by a healthcare professional using lab tests.

2 Stars
Celiac Disease and Iron Deficiency
Consult a qualified healthcare practitioner
The malabsorption that occurs in celiac disease can lead to multiple nutritional deficiencies. Supplementing with iron may correct a deficiency.

The malabsorption that occurs in celiac disease can lead to multiple nutritional deficiencies. The most common nutritional problems in people with celiac disease include deficiencies of essential fatty acids, , vitamin D, vitamin K, calcium, magnesium, and folic acid.Zinc malabsorption also occurs frequently in celiac disease and may result in zinc deficiency, even in people who are otherwise in remission. People with newly diagnosed celiac disease should be assessed for nutritional deficiencies by a doctor. Celiac patients who have not yet completely recovered should supplement with a high-potency multivitamin-mineral. Some patients may require even higher amounts of some of these vitamins and minerals—an issue that should be discussed with their healthcare practitioner. Evidence of a nutrient deficiency in a celiac patient is a clear indication for supplementation with that nutrient.

After commencement of a gluten-free diet, overall nutritional status gradually improves. However, deficiencies of some nutrients may persist, even in people who are strictly avoiding gluten. For example, magnesium deficiency was found in 8 of 23 adults with celiac disease who had been following a gluten-free diet and were symptom-free. When these adults were supplemented with magnesium for two years, their bone mineral density increased significantly.

2 Stars
Chronic Fatigue Syndrome
Refer to label instructions
In a double-blind trial, supplementing with iron significantly improved fatigue in women who were iron-deficient but not anemic.
Iron-deficiency anemia is a well-known cause of fatigue. Fatigue that is due to iron-deficiency anemia usually improves after iron supplementation. Iron deficiency in the absence of anemia can also cause fatigue, because iron plays a role in various biochemical processes involved in energy production. In a double-blind trial, supplementing with 80 mg per day of iron for 12 weeks, significantly improved fatigue compared with a placebo in women who were iron-deficient but not anemic. Iron supplementation has the potential to cause harm in people who are not deficient, so it should only be used when iron deficiency has been documented by laboratory testing.
2 Stars
Hives
If blood iron levels are low; take only under medical supervision.
Among those with chronic hives and low iron levels, supplementation with iron resulted in improvement in the hives in most cases.
Approximately two-thirds of people with chronic hives (hives present for more than 6 weeks) have low blood levels of iron. Among those with low iron levels, supplementation with iron for 1 to 2 months resulted in marked improvement in the hives in most cases. Iron supplementation has the potential to cause side effects, which in some case can be severe. For that reason, iron should not be taken without supervision by a healthcare professional.
2 Stars
Iron-Deficiency Anemia (Vitamin A)
Consult a qualified healthcare practitioner
Taking vitamin A and iron together has been reported to help overcome iron deficiency more effectively than iron supplements alone.

Taking vitamin A and iron together has been reported to help overcome iron deficiency more effectively than iron supplements alone. Although the optimal amount of vitamin A needed to help people with iron deficiency has yet to be established, some doctors recommend 10,000 IU per day.

2 Stars
Night Blindness and Iron Deficiency
30 mg of iron and 6 mg of riboflavin per day
If a person has deficiencies of iron and riboflavin, supplementing with these nutrients may increase the benefits of vitamin A.

In a study of women in Nepal, where there is a high prevalence of and riboflavin deficiencies, supplementation with 30 mg per day of iron and 6 mg per day of riboflavin for six weeks enhanced the effectiveness of vitamin A in the treatment of night blindness. It is not known whether these nutrients would be helpful for night blindness in people who are not deficient.

2 Stars
Pre- and Post-Surgery Health
Consult a qualified healthcare practitioner
Iron supplementation prior to surgery was found in one trial to reduce the need for postoperative blood transfusions.

One preliminary study found levels to be reduced after both minor and major surgeries, and iron supplementation prior to surgery was not able to prevent this reduction. A controlled trial found that intravenous iron was more effective than oral iron for restoring normal iron levels after spinal surgery in children. One animal study reported that supplementation with fructo-oligosaccharides (FOS) improved the absorption of iron and prevented anemia after surgery, but no human trials have been done to confirm this finding. Some researchers speculate that iron deficiency after a trauma such as surgery is an important mechanism for avoiding infection, and they suggest that iron supplements should not be given after surgery.

Patients who have undergone major surgery frequently need blood transfusions to replace blood lost during the procedure. Studies have found that 18 to 21% of surgery patients were anemic prior to surgery, and these anemic patients required more blood after surgery than did non-anemic surgery patients. Supplementation with iron prior to surgery was found in a controlled trial to reduce the need for blood transfusions, whether or not iron deficiency was present. supplements (99 mg per day) given before and for two months after joint surgery in another controlled trial improved blood values but did not change the length of hospitalization or the risk of post-operative fever. Pre-operative iron supplementation in combination with a medication that stimulates red blood cell production in the bone marrow is considered by some doctors to be an effective way to minimize the need for post-operative blood transfusions.

2 Stars
Pregnancy and Postpartum Support
Consult a qualified healthcare practitioner
Iron requirements increase during pregnancy, making iron deficiency in pregnancy quite common. Supplementation may help prevent a deficiency.

requirements increase during pregnancy, making iron deficiency in pregnancy quite common. Iron supplement use in the United States is estimated at 85% during pregnancy, with most women taking supplements three or more times per week for three months. Pregnant women with a documented iron deficiency need doctor-supervised treatment. In one study, 65% of women who were not given extra iron developed iron deficiency during pregnancy, compared with none who received an iron supplement. However, there is a clear increase in reported side effects with increasing supplement amounts of iron, especially iron sulfate. Supplementation with large amounts of iron has also been shown to reduce blood levels of zinc. Although the significance of that finding is not clear, low blood levels of zinc have been associated with an increased risk of complications in both the mother and fetus.

Iron supplementation was associated in one study with an increased incidence of birth defects, possibly as a result of an iron-induced deficiency of zinc. Although additional research needs to be done, the evidence suggests that women who are supplementing with iron during pregnancy should also take a multivitamin-mineral formula that contains adequate amounts of zinc. To be on the safe side, pregnant women should discuss their supplement program with a doctor.

2 Stars
Restless Legs Syndrome and Iron Deficiency
Consult a qualified healthcare practitioner
When iron deficiency is the cause of restless leg syndrome, supplementing with iron may reduce the severity of the symptoms.

Mild iron deficiency is common, even in people who are not anemic. When iron deficiency is the cause of RLS, supplementation with has been reported to reduce the severity of the symptoms. In one trial, 74 mg of iron taken three times a day for two months, reduced symptoms in people with RLS. In people who are not deficient in iron, iron supplementation has been reported to not help reduce symptoms of RLS. Most people are not iron deficient, and taking too much can lead to adverse effects. Therefore, iron supplements should only be taken by people who have a diagnosed deficiency.

1 Star
Alzheimer’s Disease (Coenzyme Q10, Vitamin B6)
Refer to label instructions
A combination of coenzyme Q10, iron (sodium ferrous citrate), and vitamin B6 may improve mental status in people with Alzheimer’s disease.

In a preliminary report, two people with a hereditary form of Alzheimer’s disease received daily: coenzyme Q10 (60 mg), (150 mg of sodium ferrous citrate), and vitamin B6 (180 mg). Mental status improved in both patients, and one became almost normal after six months.

1 Star
Cough (For iron deficiency)
Refer to label instructions
In a study of women with iron deficiency and a chronic unexplained cough, supplementation with iron for two months significantly improved symptoms.
In a study of women with iron deficiency and a chronic unexplained cough, supplementation with iron for two months significantly improved symptoms. Since iron supplementation can be harmful for people who are not deficient, iron levels should be checked with a blood test before taking iron supplements.
1 Star
Dermatitis Herpetiformis and Iron Deficiency
Refer to label instructions
Talk to your doctor to see if supplementing with iron can counteract the nutrient deficiency that often occurs as a result of malabsorption.

People with DH frequently have mild malabsorption (difficulty absorbing certain nutrients) associated with low stomach acid (hypochlorhydria) and inflammation of the stomach lining (atrophic gastritis). Mild malabsorption may result in anemia and nutritional deficiencies of , folic acid,vitamin B12, and zinc. More severe malabsorption may result in loss of bone mass. Additional subtle deficiencies of vitamins and minerals are possible, but have not been investigated. Therefore, some doctors recommend people with DH have their nutritional status checked regularly with laboratory studies. These doctors may also recommend multivitamin-mineral supplements and, to correct the low stomach acid, supplemental betaine HCl (a source of hydrochloric acid).

1 Star
Female Infertility and Iron Deficiency
Refer to label instructions
Even subtle iron deficiencies have been tentatively linked to infertility. Women who are infertile should consult a doctor to rule out the possibility of iron deficiency

In preliminary research, even a subtle deficiency of has been tentatively linked to infertility. Women who are infertile should consult a doctor to rule out the possibility of iron deficiency.

1 Star
HIV and AIDS Support
Refer to label instructions
Iron deficiency is often present in HIV-positive children. Supplementing with it, under a doctor's supervision, may support immune function.

deficiency is often present in HIV-positive children. While iron is necessary for normal immune function, iron deficiency also appears to protect against certain bacterial infections. Iron supplementation could therefore increase the severity of bacterial infections in people with AIDS. For that reason, people with HIV infection or AIDS should consult a doctor before supplementing with iron.

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